There is a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to reduce afferent soreness transmission and deliver analgesia. As a result, medications like clonidine that goal alpha-two receptors can affect the transmission of soreness. Clonidine is distributed in breast https://social4geek.com/story5376171/the-2-minute-rule-for-onolidine