In this article, we clearly show that conolidine, a purely natural analgesic alkaloid used in classic Chinese medicine, targets ACKR3, therefore giving added evidence of a correlation in between ACKR3 and suffering modulation and opening option therapeutic avenues with the cure of chronic suffering. The "Up to date" date https://simonoixod.activoblog.com/33060817/everything-about-what-is-conolidine